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@ARTICLE{Seger:893096,
      author       = {Seger, Aline and Farrher, Ezequiel and Doppler, Christopher
                      E. J. and Gogishvili, Ana and Worthoff, Wieland A. and
                      Filss, Christian P. and Barbe, Michael T. and Holtbernd,
                      Florian and Shah, N. Jon and Fink, Gereon R. and Sommerauer,
                      Michael},
      title        = {{P}utaminal y ‐{A}minobutyric {A}cid {M}odulates {M}otor
                      {R}esponse to {D}opaminergic {T}herapy in {P}arkinson's
                      {D}isease},
      journal      = {Movement disorders},
      volume       = {36},
      number       = {9},
      issn         = {1531-8257},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2021-02555},
      pages        = {2187-2192},
      year         = {2021},
      abstract     = {BackgroundMotor response to dopaminergic therapy is a
                      characteristic of patients with Parkinson's disease (PD).
                      Whether nondopaminergic neurotransmitters contribute to
                      treatment response is uncertain.ObjectivesThe aim of this
                      study is to determine whether putaminal y-aminobutyric acid
                      (GABA) levels are associated with dopaminergic motor
                      response.MethodsWe assessed putaminal GABA levels in 19 PD
                      patients and 13 healthy controls (HCs) utilizing ultra-high
                      field proton magnetic resonance spectroscopy. Motor
                      performance was evaluated using the Movement Disorder
                      Society—Unified Parkinson's Disease Rating Scale, Part
                      III, in the ON and OFF states. Statistical analysis
                      comprised group comparisons, correlation analysis, and
                      multiple linear regression.ResultsIn PD, GABA levels were
                      significantly higher compared to HCs (1.50 ± 0.26 mM
                      vs. 1.26 ± 0.31 mM, P = 0.022). Furthermore, GABA
                      levels were independent predictors of absolute and relative
                      dopaminergic treatment response.ConclusionsOur findings
                      indicate that elevated putaminal GABA levels are associated
                      with worse dopaminergic response in PD, emphasizing the
                      essential role of nondopaminergic neurotransmitters in motor
                      response. © 2021 The Authors. Movement Disorders published
                      by Wiley Periodicals LLC on behalf of International
                      Parkinson and Movement Disorder Society},
      cin          = {INM-4 / INM-3 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)INM-11-20170113 / I:(DE-Juel1)VDB1046},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34096652},
      UT           = {WOS:000658342200001},
      doi          = {10.1002/mds.28674},
      url          = {https://juser.fz-juelich.de/record/893096},
}