Journal Article

FZJ-2021-02555

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Putaminal y ‐Aminobutyric Acid Modulates Motor Response to Dopaminergic Therapy in Parkinson's Disease

Seger, A.FZJ* ; Farrher, E.FZJ* ; Doppler, C. E. J.FZJ* ; Gogishvili, A.FZJ* ; Worthoff, W. A.FZJ* ; Filss, C. P.FZJ* ; Barbe, M. T. ; Holtbernd, F.FZJ* ; Shah, N. J.FZJ* ; Fink, G. R.FZJ* ; Sommerauer, M. (Corresponding author)FZJ*

2021
Wiley New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/28785  doi:10.1002/mds.28674

Abstract: BackgroundMotor response to dopaminergic therapy is a characteristic of patients with Parkinson's disease (PD). Whether nondopaminergic neurotransmitters contribute to treatment response is uncertain.ObjectivesThe aim of this study is to determine whether putaminal y-aminobutyric acid (GABA) levels are associated with dopaminergic motor response.MethodsWe assessed putaminal GABA levels in 19 PD patients and 13 healthy controls (HCs) utilizing ultra-high field proton magnetic resonance spectroscopy. Motor performance was evaluated using the Movement Disorder Society—Unified Parkinson's Disease Rating Scale, Part III, in the ON and OFF states. Statistical analysis comprised group comparisons, correlation analysis, and multiple linear regression.ResultsIn PD, GABA levels were significantly higher compared to HCs (1.50 ± 0.26 mM vs. 1.26 ± 0.31 mM, P = 0.022). Furthermore, GABA levels were independent predictors of absolute and relative dopaminergic treatment response.ConclusionsOur findings indicate that elevated putaminal GABA levels are associated with worse dopaminergic response in PD, emphasizing the essential role of nondopaminergic neurotransmitters in motor response. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. Kognitive Neurowissenschaften (INM-3)
3. Jara-Institut Quantum Information (INM-11)
4. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)

Appears in the scientific report 2021

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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