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@ARTICLE{Bonus:893204,
      author       = {Bonus, Michele and Häussinger, Dieter and Gohlke, Holger},
      title        = {{L}iver cell hydration and integrin signaling},
      journal      = {Biological chemistry},
      volume       = {402},
      number       = {9},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2021-02621},
      pages        = {1033-1045},
      year         = {2021},
      abstract     = {Liver cell hydration (cell volume) is dynamic and can
                      change within minutes under theinfluence of hormones,
                      nutrients, and oxidative stress. Such volume changes were
                      identified asa novel and important modulator of cell
                      function. It provides an early example for theinteraction
                      between a physical parameter (cell volume) on the one hand
                      and metabolism,transport, and gene expression on the other.
                      Such events involve mechanotransduction(osmosensing) which
                      triggers signaling cascades towards liver function
                      (osmosignaling). Thisarticle reviews our own work on this
                      topic with emphasis on the role of β1 integrins
                      as(osmo-)mechanosensors in the liver, but also on their role
                      in bile acid signaling.},
      cin          = {IBG-4 / NIC / JSC / IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-4-20200403 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / 2171 - Biological and environmental resources
                      for sustainable use (POF4-217) / 2172 - Utilization of
                      renewable carbon and energy sources and engineering of
                      ecosystem functions (POF4-217) / Forschergruppe Gohlke
                      $(hkf7_20200501)$ / 5111 - Domain-Specific Simulation $\&$
                      Data Life Cycle Labs (SDLs) and Research Groups (POF4-511)},
      pid          = {G:(DE-HGF)POF3-511 / G:(DE-HGF)POF4-2171 /
                      G:(DE-HGF)POF4-2172 / $G:(DE-Juel1)hkf7_20200501$ /
                      G:(DE-HGF)POF4-5111},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33915604},
      UT           = {WOS:000685568800004},
      doi          = {10.1515/hsz-2021-0193},
      url          = {https://juser.fz-juelich.de/record/893204},
}