Journal Article

FZJ-2021-02621

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Liver cell hydration and integrin signaling

Bonus, M. ; Häussinger, D. (Corresponding author) ; Gohlke, H. (Corresponding author)FZJ*

2021
de Gruyter Berlin [u.a.]

This record in other databases:    

Please use a persistent id in citations: http://hdl.handle.net/2128/28508  doi:10.1515/hsz-2021-0193

Abstract: Liver cell hydration (cell volume) is dynamic and can change within minutes under theinfluence of hormones, nutrients, and oxidative stress. Such volume changes were identified asa novel and important modulator of cell function. It provides an early example for theinteraction between a physical parameter (cell volume) on the one hand and metabolism,transport, and gene expression on the other. Such events involve mechanotransduction(osmosensing) which triggers signaling cascades towards liver function (osmosignaling). Thisarticle reviews our own work on this topic with emphasis on the role of β1 integrins as(osmo-)mechanosensors in the liver, but also on their role in bile acid signaling.

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Contributing Institute(s):

1. Bioinformatik (IBG-4)
2. John von Neumann - Institut für Computing (NIC)
3. Jülich Supercomputing Center (JSC)
4. Strukturbiochemie (IBI-7)

Research Program(s):

1. 511 - Computational Science and Mathematical Methods (POF3-511) (POF3-511)
2. 2171 - Biological and environmental resources for sustainable use (POF4-217) (POF4-217)
3. 2172 - Utilization of renewable carbon and energy sources and engineering of ecosystem functions (POF4-217) (POF4-217)
4. Forschergruppe Gohlke (hkf7_20200501) (hkf7_20200501)
5. 5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511) (POF4-511)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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