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@ARTICLE{Gertzen:893211,
      author       = {Gertzen, Christoph G. W. and Gohlke, Holger and
                      Häussinger, Dieter and Herebian, Diran and Keitel, Verena
                      and Kubitz, Ralf and Mayatepek, Ertan and Schmitt, Lutz},
      title        = {{T}he many facets of bile acids in the physiology and
                      pathophysiology of the human liver},
      journal      = {Biological chemistry},
      volume       = {402},
      number       = {9},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2021-02628},
      pages        = {1047-1062},
      year         = {2021},
      abstract     = {Bile acids perform vital functions in the human liver and
                      are the essential component of bile. It is therefore not
                      surprising that the biology of bile acids is extremely
                      complex, regulated on different levels, and involves soluble
                      and membrane receptors as well as transporters. Hereditary
                      disorders of these proteins manifest in different
                      pathophysiological processes that result in liver diseases
                      of varying severity. In this review, we summarize our
                      current knowledge of the physiology and pathophysiology of
                      bile acids with an emphasis on recently established
                      analytical approaches as well as the molecular mechanisms
                      that underlie signaling and transport of bile acids. In this
                      review, we will focus on ABC transporters of the canalicular
                      membrane and their associated diseases. As the G
                      protein-coupled receptor, TGR5, receives increasing
                      attention, we have included aspects of this receptor and its
                      interaction with bile acids.},
      cin          = {IBG-4 / NIC / JSC / IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-4-20200403 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / 5111 - Domain-Specific Simulation $\&$ Data
                      Life Cycle Labs (SDLs) and Research Groups (POF4-511) / 2171
                      - Biological and environmental resources for sustainable use
                      (POF4-217) / 2172 - Utilization of renewable carbon and
                      energy sources and engineering of ecosystem functions
                      (POF4-217) / Forschergruppe Gohlke $(hkf7_20200501)$},
      pid          = {G:(DE-HGF)POF3-511 / G:(DE-HGF)POF4-5111 /
                      G:(DE-HGF)POF4-2171 / G:(DE-HGF)POF4-2172 /
                      $G:(DE-Juel1)hkf7_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34049433},
      UT           = {WOS:000685568800005},
      doi          = {10.1515/hsz-2021-0156},
      url          = {https://juser.fz-juelich.de/record/893211},
}