Journal Article

FZJ-2021-02628

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The many facets of bile acids in the physiology and pathophysiology of the human liver

Gertzen, C. G. W. ; Gohlke, H.FZJ* ; Häussinger, D. ; Herebian, D. ; Keitel, V. ; Kubitz, R. ; Mayatepek, E. ; Schmitt, L. (Corresponding author)

2021
de Gruyter Berlin [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/28509  doi:10.1515/hsz-2021-0156

Abstract: Bile acids perform vital functions in the human liver and are the essential component of bile. It is therefore not surprising that the biology of bile acids is extremely complex, regulated on different levels, and involves soluble and membrane receptors as well as transporters. Hereditary disorders of these proteins manifest in different pathophysiological processes that result in liver diseases of varying severity. In this review, we summarize our current knowledge of the physiology and pathophysiology of bile acids with an emphasis on recently established analytical approaches as well as the molecular mechanisms that underlie signaling and transport of bile acids. In this review, we will focus on ABC transporters of the canalicular membrane and their associated diseases. As the G protein-coupled receptor, TGR5, receives increasing attention, we have included aspects of this receptor and its interaction with bile acids.

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Contributing Institute(s):

1. Bioinformatik (IBG-4)
2. John von Neumann - Institut für Computing (NIC)
3. Jülich Supercomputing Center (JSC)
4. Strukturbiochemie (IBI-7)

Research Program(s):

1. 511 - Computational Science and Mathematical Methods (POF3-511) (POF3-511)
2. 5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511) (POF4-511)
3. 2171 - Biological and environmental resources for sustainable use (POF4-217) (POF4-217)
4. 2172 - Utilization of renewable carbon and energy sources and engineering of ecosystem functions (POF4-217) (POF4-217)
5. Forschergruppe Gohlke (hkf7_20200501) (hkf7_20200501)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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