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@ARTICLE{Dasanna:894167,
      author       = {Dasanna, Anil K and Hillringhaus, Sebastian and Gompper,
                      Gerhard and Fedosov, Dmitry A},
      title        = {{E}ffect of malaria parasite shape on its alignment at
                      erythrocyte membrane},
      journal      = {eLife},
      volume       = {10},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2021-03069},
      pages        = {e68818},
      year         = {2021},
      abstract     = {During the blood stage of malaria pathogenesis, parasites
                      invade healthy red blood cells (RBC) to multiply inside the
                      host and evade the immune response. When attached to RBC,
                      the parasite first has to align its apex with the membrane
                      for a successful invasion. Since the parasite's apex sits at
                      the pointed end of an oval (egg-like) shape with a large
                      local curvature, apical alignment is in general an
                      energetically un-favorable process. Previously, using
                      coarse-grained mesoscopic simulations, we have shown that
                      optimal alignment time is achieved due to RBC membrane
                      deformation and the stochastic nature of bond-based
                      interactions between the parasite and RBC membrane
                      (Hillringhaus et al., 2020). Here, we demonstrate that the
                      parasite's shape has a prominent effect on the alignment
                      process. The alignment times of spherical parasites for
                      intermediate and large bond off-rates (or weak
                      membrane-parasite interactions) are found to be close to
                      those of an egg-like shape. However, for small bond
                      off-rates (or strong adhesion and large membrane
                      deformations), the alignment time for a spherical shape
                      increases drastically. Parasite shapes with large aspect
                      ratios such as oblate and long prolate ellipsoids are found
                      to exhibit very long alignment times in comparison to the
                      egg-like shape. At a stiffened RBC, spherical parasite
                      aligns faster than any other investigated shapes. This study
                      shows that the original egg-like shape performs not worse
                      for parasite alignment than other considered shapes, but is
                      more robust with respect to different adhesion interactions
                      and RBC membrane rigidities.},
      cin          = {IBI-5},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-5-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34286696},
      UT           = {WOS:000683010100001},
      doi          = {10.7554/eLife.68818},
      url          = {https://juser.fz-juelich.de/record/894167},
}