% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Nassiri:894308,
      author       = {Nassiri, Farshad and Wang, Justin Z and Singh, Olivia and
                      Karimi, Shirin and Dalcourt, Tatyana and Ijad, Nazanin and
                      Pirouzmand, Neda and Ng, Ho-Keung and Saladino, Andrea and
                      Pollo, Bianca and Dimeco, Francesco and Yip, Stephen and
                      Gao, Andrew and Aldape, Kenneth D and Zadeh, Gelareh and
                      Aldape, Kenneth and Au, Karolyn and Barnholtz-Sloan, Jill
                      and Behling, Felix and Bi, Wenya and Brastianos, Priscilla
                      and Butowski, Nicholas and Brodie, Chaya and Cohen-Gadol,
                      Aaron and Couce, Marta and Dimeco, Francesco and Drummond,
                      Kate and Dunn, Ian and Cohen-Gadol, Aaron and Galanis, Eva
                      and Galldiks, Norbert and Giannini, Caterina and
                      Goldbrunner, Roland and Hanemann, Oliver and Herold-Mende,
                      Christel and Horbinski, Craig and Huang, Raymond and
                      Javadpour, Mohsen and Jenkinson, Michael and Jungk,
                      Christine and Kaufmann, Timothy and Krischek, Boris and
                      Kurz, Sylvia and Lachance, Daniel and Lafougere, Christian
                      and Lamszus, Katrin and Lee, Ian and Malta, Tathiana and
                      Makarenko, Serge and Mawrin, Christian and McDermott,
                      Michael and Millward, Christopher and Moliterno-Gunel,
                      Jennifer and Morokoff, Andrew and Nassiri, Farshad and Ng,
                      H. K. and Noushmehr, Houtan and Perry, Arie and Poisson,
                      Laila and Pollo, Bianco and Ragunathan, Aditya and Raleigh,
                      David and Renovanz, Mirjam and Ricklefs, Franz and Sahm,
                      Felix and Saladino, Andrea and Santacroce, Antonio and
                      Santarius, Thomas and Schichor, Christian and Schimdt, Nils
                      and Schittenhelm, Jens and Selman, Warren and Shih, Helen
                      and Snyder, Jim and Snuderl, Matja and Sloan, Andrew and
                      Suppiah, Suganth and Sulman, Erik and Tabatabai, Ghazaleh
                      and Tatagiba, Marcos and Timmer, Marcos and Tonn,
                      Joerg-Christian and Von Deimling, Andreas and Vogelbaum,
                      Michael and Walbert, Tobias and Wang, Justin and Wen,
                      Patrick and Westphal, Manfred and Yip, Stephen and Zadeh,
                      Gelareh},
      title        = {{L}oss of {H}3{K}27me3 in meningiomas},
      journal      = {Neuro-Oncology},
      volume       = {23},
      number       = {8},
      issn         = {1523-5866},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2021-03168},
      pages        = {1282 - 1291},
      year         = {2021},
      abstract     = {BackgroundThere is a critical need for objective and
                      reliable biomarkers of outcome in meningiomas beyond WHO
                      classification. Loss of H3K27me3 has been reported as a
                      prognostically unfavorable alteration in meningiomas. We
                      sought to independently evaluate the reproducibility and
                      prognostic value of H3K27me3 loss by immunohistochemistry
                      (IHC) in a multicenter study.MethodsIHC staining for
                      H3K27me3 and analyses of whole slides from 181 meningiomas
                      across three centers was performed. Staining was analyzed by
                      dichotomization into loss and retained immunoreactivity, and
                      using a 3-tiered scoring system in 151 cases with clear
                      staining. Associations of grouping with outcome were
                      performed using Kaplan-Meier survival estimates.ResultsA
                      total of 21 of 151 tumors $(13.9\%)$ demonstrated complete
                      loss of H3K27me3 staining in tumor with retained endothelial
                      staining. Overall, loss of H3K27me3 portended a worse
                      outcome with shorter times to recurrence in our cohort,
                      particularly for WHO grade 2 tumors which were enriched in
                      our study. There were no differences in recurrence-free
                      survival (RFS) for WHO grade 3 patients with retained vs
                      loss of H3K27me3. Scoring by a 3-tiered system did not add
                      further insights into the prognostic value of this H3K27me3
                      loss. Overall, loss of H3K27me3 was not independently
                      associated with RFS after controlling for WHO grade, extent
                      of resection, sex, age, and recurrence status of tumor on
                      multivariable Cox regression analysis.ConclusionsLoss of
                      H3K27me3 identifies a subset of WHO grade 2 and possibly WHO
                      grade 1 meningiomas with increased recurrence risk. Pooled
                      analyses of a larger cohort of samples with standardized
                      reporting of clinical definitions and staining patterns are
                      warranted.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33970242},
      UT           = {WOS:000685248000012},
      doi          = {10.1093/neuonc/noab036},
      url          = {https://juser.fz-juelich.de/record/894308},
}