%0 Journal Article
%A Brands, Stefanie
%A Sikkens, Jarno G.
%A Davari, Mehdi D.
%A Brass, Hannah
%A Klein, Andreas
%A Pietruszka, Jörg
%A Ruff, Anna Joëlle
%A Schwaneberg, Ulrich
%T Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels
%J Chemical communications
%V 57
%N 21
%@ 1364-548X
%C Cambridge
%I Soc.
%M FZJ-2021-03549
%P 2681 - 2684
%D 2021
%X Semi-rational redesign of the substrate binding pocket and access tunnels of prodigiosin ligase PigC enhanced the catalytic efficiency in the synthesis of pyrrolic anti-cancer agents more than 45 times. A molecular understanding was gained on residues V333 and T334 relevant to substrate binding and translocation of small pyrroles through PigC access tunnels.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 33595019
%U <Go to ISI:>//WOS:000627549600019
%R 10.1039/D0CC08226K
%U https://juser.fz-juelich.de/record/896716