Journal Article

FZJ-2021-03549

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels

Brands, S.RWTH* ; Sikkens, J. G.RWTH* ; Davari, M. D.RWTH* ; Brass, H.FZJ* ; Klein, A. ; Pietruszka, J.FZJ* ; Ruff, A. J.RWTH* ; Schwaneberg, U. (Corresponding author)RWTH*

2021
Soc. Cambridge

This record in other databases:    

Please use a persistent id in citations: http://hdl.handle.net/2128/29752  doi:10.1039/D0CC08226K

Abstract: Semi-rational redesign of the substrate binding pocket and access tunnels of prodigiosin ligase PigC enhanced the catalytic efficiency in the synthesis of pyrrolic anti-cancer agents more than 45 times. A molecular understanding was gained on residues V333 and T334 relevant to substrate binding and translocation of small pyrroles through PigC access tunnels.

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Contributing Institute(s):

1. Institut für Bioorganische Chemie (HHUD) (IBOC)
2. Biotechnologie (IBG-1)

Research Program(s):

1. 2171 - Biological and environmental resources for sustainable use (POF4-217) (POF4-217)

Appears in the scientific report 2021

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Database coverage:
; ; Allianz-Lizenz / DFG ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; Index Chemicus ; JCR ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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