TY  - JOUR
AU  - Brands, Stefanie
AU  - Sikkens, Jarno G.
AU  - Davari, Mehdi D.
AU  - Brass, Hannah
AU  - Klein, Andreas
AU  - Pietruszka, Jörg
AU  - Ruff, Anna Joëlle
AU  - Schwaneberg, Ulrich
TI  - Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels
JO  - Chemical communications
VL  - 57
IS  - 21
SN  - 1364-548X
CY  - Cambridge
PB  - Soc.
M1  - FZJ-2021-03549
SP  - 2681 - 2684
PY  - 2021
AB  - Semi-rational redesign of the substrate binding pocket and access tunnels of prodigiosin ligase PigC enhanced the catalytic efficiency in the synthesis of pyrrolic anti-cancer agents more than 45 times. A molecular understanding was gained on residues V333 and T334 relevant to substrate binding and translocation of small pyrroles through PigC access tunnels.
LB  - PUB:(DE-HGF)16
C6  - 33595019
UR  - <Go to ISI:>//WOS:000627549600019
DO  - DOI:10.1039/D0CC08226K
UR  - https://juser.fz-juelich.de/record/896716
ER  -