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@ARTICLE{Brands:896716,
      author       = {Brands, Stefanie and Sikkens, Jarno G. and Davari, Mehdi D.
                      and Brass, Hannah and Klein, Andreas and Pietruszka, Jörg
                      and Ruff, Anna Joëlle and Schwaneberg, Ulrich},
      title        = {{U}nderstanding substrate binding and the role of
                      gatekeeping residues in {P}ig{C} access tunnels},
      journal      = {Chemical communications},
      volume       = {57},
      number       = {21},
      issn         = {1364-548X},
      address      = {Cambridge},
      publisher    = {Soc.},
      reportid     = {FZJ-2021-03549},
      pages        = {2681 - 2684},
      year         = {2021},
      abstract     = {Semi-rational redesign of the substrate binding pocket and
                      access tunnels of prodigiosin ligase PigC enhanced the
                      catalytic efficiency in the synthesis of pyrrolic
                      anti-cancer agents more than 45 times. A molecular
                      understanding was gained on residues V333 and T334 relevant
                      to substrate binding and translocation of small pyrroles
                      through PigC access tunnels.},
      cin          = {IBOC / IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBOC-20090406 / I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33595019},
      UT           = {WOS:000627549600019},
      doi          = {10.1039/D0CC08226K},
      url          = {https://juser.fz-juelich.de/record/896716},
}