Home > Publications database > Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels > print

001     896716
005     20220126162549.0
024 7 _ |a 10.1039/D0CC08226K
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024 7 _ |a 1364-548X
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024 7 _ |a 2050-5620
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024 7 _ |a 2050-5639
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024 7 _ |a 2128/29752
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024 7 _ |a 33595019
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100 1 _ |a Brands, Stefanie
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245 _ _ |a Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels
260 _ _ |a Cambridge
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520 _ _ |a Semi-rational redesign of the substrate binding pocket and access tunnels of prodigiosin ligase PigC enhanced the catalytic efficiency in the synthesis of pyrrolic anti-cancer agents more than 45 times. A molecular understanding was gained on residues V333 and T334 relevant to substrate binding and translocation of small pyrroles through PigC access tunnels.
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700 1 _ |a Sikkens, Jarno G.
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700 1 _ |a Davari, Mehdi D.
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700 1 _ |a Brass, Hannah
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700 1 _ |a Klein, Andreas
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700 1 _ |a Pietruszka, Jörg
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700 1 _ |a Ruff, Anna Joëlle
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700 1 _ |a Schwaneberg, Ulrich
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773 _ _ |a 10.1039/D0CC08226K
|g Vol. 57, no. 21, p. 2681 - 2684
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856 4 _ |y Published on 2021-02-02. Available in OpenAccess from 2022-02-02.
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