TY  - JOUR
AU  - Kohle, Felix
AU  - Sprenger, Alina
AU  - Klein, Ines
AU  - Fink, Gereon R.
AU  - Lehmann, Helmar C.
TI  - Nerve conductions studies in experimental models of autoimmune neuritis: A meta-analysis and guideline
JO  - Journal of neuroimmunology
VL  - 352
SN  - 0165-5728
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2021-03565
SP  - 577470 -
PY  - 2021
N1  - Bitte Post-print ergänzen
AB  - Nerve conduction studies (NCS) are essential to assess peripheral nerve fiber function in research models of immune-mediated neuritis. However, the current lack of standard protocols and reference values impedes data comparability across models and studies. We performed a systematic review and subsequent meta-analysis of the last 30 years of NCS of immune-mediated neuritis in Lewis-rats. Twenty-six papers met the inclusion criteria for meta-analysis. Extracted data showed considerable heterogeneity of recorded nerve conduction velocity (NCV) and compound muscle action potential (CMAP). Studies also significantly differed in terms of technical, methodical, and data reporting issues. The heterogeneity of the underlying studies emphasizes the need for standardization when conducting and reporting NCS in rats. We provide normative values for NCS of the sciatic nerve of Lewis rats and propose seven items that should be addressed when NCS are performed when studying immune paradigms in Lewis rats.
LB  - PUB:(DE-HGF)16
C6  - 33508768
UR  - <Go to ISI:>//WOS:000640526200009
DO  - DOI:10.1016/j.jneuroim.2020.577470
UR  - https://juser.fz-juelich.de/record/896740
ER  -