Journal Article

FZJ-2021-03565

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Nerve conductions studies in experimental models of autoimmune neuritis: A meta-analysis and guideline

Kohle, F. (Corresponding author) ; Sprenger, A. ; Klein, I. ; Fink, G. R.FZJ* ; Lehmann, H. C.

2021
Elsevier Science Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: http://hdl.handle.net/2128/28865  doi:10.1016/j.jneuroim.2020.577470

Abstract: Nerve conduction studies (NCS) are essential to assess peripheral nerve fiber function in research models of immune-mediated neuritis. However, the current lack of standard protocols and reference values impedes data comparability across models and studies. We performed a systematic review and subsequent meta-analysis of the last 30 years of NCS of immune-mediated neuritis in Lewis-rats. Twenty-six papers met the inclusion criteria for meta-analysis. Extracted data showed considerable heterogeneity of recorded nerve conduction velocity (NCV) and compound muscle action potential (CMAP). Studies also significantly differed in terms of technical, methodical, and data reporting issues. The heterogeneity of the underlying studies emphasizes the need for standardization when conducting and reporting NCS in rats. We provide normative values for NCS of the sciatic nerve of Lewis rats and propose seven items that should be addressed when NCS are performed when studying immune paradigms in Lewis rats.

Note: Bitte Post-print ergänzen

---

Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2021

---

Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---