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@PHDTHESIS{Liu:897091,
      author       = {Liu, Xiaojin},
      title        = {{M}ulti-modal {P}arcellation of the {H}uman {S}triatum:
                      {F}unctions, {C}linical{R}elevance and its {S}pecific
                      {C}onnectivity},
      school       = {Heinrich Heine University Düsseldorf},
      type         = {Dissertation},
      reportid     = {FZJ-2021-03590},
      pages        = {-},
      year         = {2021},
      note         = {Dissertation, Heinrich Heine University Düsseldorf, 2021},
      abstract     = {The human striatum is a part of subcortical nuclei and
                      plays an important role in both cognitive andmotor
                      functions. Its dysfunction has been implicated in the
                      pathophysiology of various disorders,including Parkinson’s
                      disease (PD) and schizophrenia (SCZ). The human striatum is
                      known to becomposed of several functionally and structurally
                      divergent subregions. However, previous studiesindependently
                      investigated its functional and structural parcellations,
                      the extent of multi-modalconvergent organization of the
                      striatum remains unclear. Also, human and macaque striatum
                      have a widehomology because in both the striatum is related
                      to several psychological and behavior
                      functions.Investigating the functional and structural
                      differences between human and macaque striatal subregionsmay
                      help us to understand the evolutionary divergence and reveal
                      why human is vulnerability to someneuropsychiatric diseases.
                      So far, the difference in functional organization of the
                      striatum with crossspeciescomparison is still unclear. In
                      this dissertation, we aimed to 1) investigate the
                      multi-modalorganization of the human striatum by jointly
                      analyzing the resting-state functional connectivity
                      (RSFC),probabilistic diffusion tractography (PDT), and
                      structural covariance (SC) and examine the structuralatrophy
                      of ensuing parcels in PD and SCZ; 2) compare human and
                      macaque striatal subregionsaccording to their homologous
                      cortico-striatal connectivity; and 3) introduced a
                      standardized toolbox‘CBPtools’ for connectivity-based
                      parcellation (CBP) analysis. In study 1 we found convergent
                      clustersin the dorsal, dorsolateral, rostral, ventral and
                      caudal striatum and observed significant structural
                      atrophyin the rostral and ventral striatum common to both PD
                      and SCZ, and atrophy specifically attributable toPD in the
                      dorsolateral striatum. In study 2, dissimilar
                      cortico-striatal RSFC within the dorsal caudatewas detected
                      through cross-species comparison. In addition, abnormal RSFC
                      was found not onlybetween dorsal caudate, but also between
                      rostral caudate, ventral, central and caudal putamen
                      andwidespread cortical regions for both PD and SCZ patients.
                      In sum, this dissertation revealed a crossmodalconvergent
                      organization of the human striatum that can be used to
                      investigate the structural andfunctional variability in
                      aging and diseases; and provided a testable hypothesis that
                      abnormalities indorsal caudate with human-specific
                      connectivity may contribute to human neuropsychiatric
                      disorders.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)11},
      url          = {https://juser.fz-juelich.de/record/897091},
}