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| Home > Publications database > Multi-modal Parcellation of the Human Striatum: Functions, ClinicalRelevance and its Specific Connectivity |
| Home > Publications database > Multi-modal Parcellation of the Human Striatum: Functions, ClinicalRelevance and its Specific Connectivity |
| Dissertation / PhD Thesis | FZJ-2021-03590 |
2021
Please use a persistent id in citations: http://hdl.handle.net/2128/28700
Abstract: The human striatum is a part of subcortical nuclei and plays an important role in both cognitive andmotor functions. Its dysfunction has been implicated in the pathophysiology of various disorders,including Parkinson’s disease (PD) and schizophrenia (SCZ). The human striatum is known to becomposed of several functionally and structurally divergent subregions. However, previous studiesindependently investigated its functional and structural parcellations, the extent of multi-modalconvergent organization of the striatum remains unclear. Also, human and macaque striatum have a widehomology because in both the striatum is related to several psychological and behavior functions.Investigating the functional and structural differences between human and macaque striatal subregionsmay help us to understand the evolutionary divergence and reveal why human is vulnerability to someneuropsychiatric diseases. So far, the difference in functional organization of the striatum with crossspeciescomparison is still unclear. In this dissertation, we aimed to 1) investigate the multi-modalorganization of the human striatum by jointly analyzing the resting-state functional connectivity (RSFC),probabilistic diffusion tractography (PDT), and structural covariance (SC) and examine the structuralatrophy of ensuing parcels in PD and SCZ; 2) compare human and macaque striatal subregionsaccording to their homologous cortico-striatal connectivity; and 3) introduced a standardized toolbox‘CBPtools’ for connectivity-based parcellation (CBP) analysis. In study 1 we found convergent clustersin the dorsal, dorsolateral, rostral, ventral and caudal striatum and observed significant structural atrophyin the rostral and ventral striatum common to both PD and SCZ, and atrophy specifically attributable toPD in the dorsolateral striatum. In study 2, dissimilar cortico-striatal RSFC within the dorsal caudatewas detected through cross-species comparison. In addition, abnormal RSFC was found not onlybetween dorsal caudate, but also between rostral caudate, ventral, central and caudal putamen andwidespread cortical regions for both PD and SCZ patients. In sum, this dissertation revealed a crossmodalconvergent organization of the human striatum that can be used to investigate the structural andfunctional variability in aging and diseases; and provided a testable hypothesis that abnormalities indorsal caudate with human-specific connectivity may contribute to human neuropsychiatric disorders.
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