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@ARTICLE{FroudistWalsh:897222,
      author       = {Froudist-Walsh, S. and Blliss, D. P. and Ding, X. and
                      Jankovic-Rapan, Lucija and Niu, Meiqi and Knoblauch, K. and
                      Zilles, Karl and Kennedy, H. and Palomero-Gallagher, Nicola
                      and Wang, X.-J.},
      title        = {{A} dopamine gradient controls access to distributed
                      working memory in large-scale monkey cortex},
      journal      = {Neuron},
      volume       = {109},
      number       = {21},
      issn         = {0896-6273},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {FZJ-2021-03684},
      pages        = {3500-3520.e13},
      year         = {2021},
      abstract     = {Dopamine is required for working memory, but how it
                      modulates the large-scale cortex is unknown. Here, we report
                      that dopamine receptor density per neuron, measured by
                      autoradiography, displays a macroscopic gradient along the
                      macaque cortical hierarchy. This gradient is incorporated in
                      a connectome-based large-scale cortex model endowed with
                      multiple neuron types. The model captures an inverted
                      U-shaped dependence of working memory on dopamine and
                      spatial patterns of persistent activity observed in over 90
                      experimental studies. Moreover, we show that dopamine is
                      crucial for filtering out irrelevant stimuli by enhancing
                      inhibition from dendrite-targeting interneurons. Our model
                      revealed that an activity-silent memory trace can be
                      realized by facilitation of inter-areal connections and that
                      adjusting cortical dopamine induces a switch from this
                      internal memory state to distributed persistent activity.
                      Our work represents a cross-level understanding from
                      molecules and cell types to recurrent circuit dynamics
                      underlying a core cognitive function distributed across the
                      primate cortex.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539) / HBP SGA2 - Human Brain Project
                      Specific Grant Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539 /
                      G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34536352},
      UT           = {WOS:000717490100003},
      doi          = {10.1016/j.neuron.2021.08.024},
      url          = {https://juser.fz-juelich.de/record/897222},
}