Journal Article

FZJ-2021-03684

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A dopamine gradient controls access to distributed working memory in large-scale monkey cortex

Froudist-Walsh, S. ; Blliss, D. P. ; Ding, X. ; Jankovic-Rapan, L.FZJ* ; Niu, M.FZJ* ; Knoblauch, K. ; Zilles, K. ; Kennedy, H. ; Palomero-Gallagher, N.FZJ* ; Wang, X.-J. (Corresponding author)

2021
Elsevier New York, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/28883  doi:10.1016/j.neuron.2021.08.024

Abstract: Dopamine is required for working memory, but how it modulates the large-scale cortex is unknown. Here, we report that dopamine receptor density per neuron, measured by autoradiography, displays a macroscopic gradient along the macaque cortical hierarchy. This gradient is incorporated in a connectome-based large-scale cortex model endowed with multiple neuron types. The model captures an inverted U-shaped dependence of working memory on dopamine and spatial patterns of persistent activity observed in over 90 experimental studies. Moreover, we show that dopamine is crucial for filtering out irrelevant stimuli by enhancing inhibition from dendrite-targeting interneurons. Our model revealed that an activity-silent memory trace can be realized by facilitation of inter-areal connections and that adjusting cortical dopamine induces a switch from this internal memory state to distributed persistent activity. Our work represents a cross-level understanding from molecules and cell types to recurrent circuit dynamics underlying a core cognitive function distributed across the primate cortex.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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