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@ARTICLE{Willms:901974,
      author       = {Willms, Sarah and Abel, Miriam and Karni, Avi and Gal,
                      Carmit and Doyon, Julien and King, Bradley R. and Classen,
                      Joseph and Rumpf, Jost-Julian and Buccino, Giovanni and
                      Pellicano, Antonello and Klann, Juliane and Binkofski,
                      Ferdinand},
      title        = {{M}otor sequence learning in patients with ideomotor
                      apraxia: {E}ffects of long-term training},
      journal      = {Neuropsychologia},
      volume       = {159},
      issn         = {0028-3932},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-03948},
      pages        = {107921 -},
      year         = {2021},
      abstract     = {Recent studies show that limb apraxia is a quite frequent,
                      yet often underdiagnosed, higher motor impairment following
                      stroke. Because it adversely affects every-day life and
                      personal independence, successful rehabilitation of apraxia
                      is essential for personal well-being. Nevertheless, evidence
                      of long-term efficacy of training schemes and generalization
                      to untrained actions is still scarce. One possible reason
                      for the tendency of this neurological disorder to persist
                      may be a deficit in planning, conceptualisation and storage
                      of complex motor acts.This pilot study aims at investigating
                      explicit motor learning in apractic stroke patients. In
                      particular, we addressed the ability of apractic patients to
                      learn and to retain new explicit sequential finger movements
                      across 10 training sessions over a 3-week interval.Nine
                      stroke patients with ideomotor apraxia in its chronic stage
                      participated in a multi-session training regimen and were
                      included in data analyses. Patients performed an explicit
                      finger sequence learning task (MSLT – motor sequence
                      learning task), which is a well-established paradigm to
                      investigate motor learning and memory processes.Patients
                      improved task performance in terms of speed and accuracy
                      across sessions. Specifically, they showed a noticeable
                      reduction in the mean time needed to perform a correct
                      sequence and the number of erroneous sequences. We found
                      also a trend for improved performance at the Goldenberg
                      apraxia test protocol: “imitation of meaningless hand and
                      finger gestures” relative to when assessed before the MSLT
                      training.Patients with ideomotor apraxia demonstrated the
                      ability to acquire and maintain a novel sequence of
                      movements; and, this training was associated with hints
                      towards improvement of apraxia symptoms.},
      cin          = {INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34181927},
      UT           = {WOS:000678172900010},
      doi          = {10.1016/j.neuropsychologia.2021.107921},
      url          = {https://juser.fz-juelich.de/record/901974},
}