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@ARTICLE{Tharmasothirajan:902400,
      author       = {Tharmasothirajan, Apilaasha and Wellfonder, M. and
                      Marienhagen, Jan},
      title        = {{M}icrobial {P}olyphenol {P}roduction in a {B}iphasic
                      {P}rocess},
      journal      = {ACS sustainable chemistry $\&$ engineering},
      volume       = {9},
      number       = {51},
      issn         = {2168-0485},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2021-04232},
      pages        = {17266-17275},
      year         = {2021},
      abstract     = {Microbial synthesis of aromatic compounds is generally
                      limited by inherent product toxicity toward the producing
                      cells. Here, in situ extractive strategies represent an
                      efficient approach to avoid such toxic effects and to
                      increase the overall process performance. We conducted a
                      solvent screening to identify suitable organic solvents to
                      develop a biphasic extractive strategy for microbial plant
                      polyphenol production using Corynebacterium glutamicum. From
                      10 pre-selected organic solvents, tributyrin (TB) showed the
                      best biocompatibility and was chosen for the biphasic
                      extraction process due to its beneficial effect on
                      partitioning and solubility of the plant polyphenol
                      resveratrol. In bioreactors, biphasic cultivation with TB
                      allowed for a product titer of 7.5 mM (1.71 g L–1)
                      resveratrol with a volumetric productivity of 0.26 mM h–1
                      and a product yield of 0.92 mol mol–1. This biphasic
                      cultivation procedure can be directly employed for the
                      synthesis of other aromatics with similar properties using
                      C. glutamicum.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000753972100008},
      doi          = {10.1021/acssuschemeng.1c05865},
      url          = {https://juser.fz-juelich.de/record/902400},
}