%0 Journal Article
%A Song, Mengmeng
%A Beyer, Leonie
%A Kaiser, Lena
%A van Eimeren, Thilo
%A Barthel, Henryk
%A Marek, Ken
%A Nitschmann, Alexander
%A Scheifele, Maximilian
%A Palleis, Carla
%A Respondek, Gesine
%A Kern, Maike
%A Biechele, Gloria
%A Hammes, Jochen
%A Bischof, Gèrard
%A Barbe, Michael
%A Onur, Özgür
%A Jessen, Frank
%A Saur, Dorothee
%A Schroeter, Matthias L
%A Rumpf, Jost-Julian
%A Rullmann, Michael
%A Schildan, Andreas
%A Patt, Marianne
%A Neumaier, Bernd
%A Barret, Olivier
%A Madonia, Jennifer
%A Russell, David S
%A Stephens, Andrew W
%A Mueller, Andre
%A Roeber, Sigrun
%A Herms, Jochen
%A Bötzel, Kai
%A Danek, Adrian
%A Levin, Johannes
%A Classen, Joseph
%A Höglinger, Günter U
%A Bartenstein, Peter
%A Villemagne, Victor
%A Drzezga, Alexander
%A Seibyl, John
%A Sabri, Osama
%A Boening, Guido
%A Ziegler, Sibylle
%A Brendel, Matthias
%T Binding characteristics of [ 18 F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET
%J Journal of cerebral blood flow & metabolism
%V 41
%N 11
%@ 0271-678X
%C London
%I Sage
%M FZJ-2021-04344
%P 2957 - 2972
%D 2021
%X The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34044665
%U <Go to ISI:>//WOS:000680595900001
%R 10.1177/0271678X211018904
%U https://juser.fz-juelich.de/record/902542