Journal Article

FZJ-2021-04344

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Binding characteristics of [ 18 F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET

Song, M. ; Beyer, L. ; Kaiser, L. ; van Eimeren, T. ; Barthel, H. ; Marek, K. ; Nitschmann, A. ; Scheifele, M. ; Palleis, C. ; Respondek, G. ; Kern, M. ; Biechele, G. ; Hammes, J.FZJ* ; Bischof, G.FZJ* ; Barbe, M. ; Onur, Ö.FZJ* ; Jessen, F. ; Saur, D. ; Schroeter, M. L. ; Rumpf, J.-J. ; Rullmann, M. ; Schildan, A. ; Patt, M. ; Neumaier, B.FZJ* ; Barret, O. ; Madonia, J. ; Russell, D. S. ; Stephens, A. W. ; Mueller, A. ; Roeber, S. ; Herms, J. ; Bötzel, K. ; Danek, A. ; Levin, J. ; Classen, J. ; Höglinger, G. U. ; Bartenstein, P. ; Villemagne, V. ; Drzezga, A.FZJ* ; Seibyl, J. ; Sabri, O. ; Boening, G. ; Ziegler, S. ; Brendel, M. (Corresponding author)

2021
Sage London

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Please use a persistent id in citations: http://hdl.handle.net/2128/29052  doi:10.1177/0271678X211018904

Abstract: The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Molekulare Organisation des Gehirns (INM-2)
3. Nuklearchemie (INM-5)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2021

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