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000902542 0247_ $$2doi$$a10.1177/0271678X211018904
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000902542 1001_ $$0P:(DE-HGF)0$$aSong, Mengmeng$$b0
000902542 245__ $$aBinding characteristics of [ 18 F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET
000902542 260__ $$aLondon$$bSage$$c2021
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000902542 520__ $$aThe novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
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000902542 7001_ $$0P:(DE-HGF)0$$aBeyer, Leonie$$b1
000902542 7001_ $$0P:(DE-HGF)0$$aKaiser, Lena$$b2
000902542 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b3
000902542 7001_ $$0P:(DE-HGF)0$$aBarthel, Henryk$$b4
000902542 7001_ $$0P:(DE-HGF)0$$aMarek, Ken$$b5
000902542 7001_ $$0P:(DE-HGF)0$$aNitschmann, Alexander$$b6
000902542 7001_ $$0P:(DE-HGF)0$$aScheifele, Maximilian$$b7
000902542 7001_ $$0P:(DE-HGF)0$$aPalleis, Carla$$b8
000902542 7001_ $$0P:(DE-HGF)0$$aRespondek, Gesine$$b9
000902542 7001_ $$0P:(DE-HGF)0$$aKern, Maike$$b10
000902542 7001_ $$0P:(DE-HGF)0$$aBiechele, Gloria$$b11
000902542 7001_ $$0P:(DE-Juel1)184744$$aHammes, Jochen$$b12$$ufzj
000902542 7001_ $$0P:(DE-Juel1)166265$$aBischof, Gèrard$$b13
000902542 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael$$b14
000902542 7001_ $$0P:(DE-Juel1)131736$$aOnur, Özgür$$b15
000902542 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b16
000902542 7001_ $$0P:(DE-HGF)0$$aSaur, Dorothee$$b17
000902542 7001_ $$0P:(DE-HGF)0$$aSchroeter, Matthias L$$b18
000902542 7001_ $$0P:(DE-HGF)0$$aRumpf, Jost-Julian$$b19
000902542 7001_ $$0P:(DE-HGF)0$$aRullmann, Michael$$b20
000902542 7001_ $$0P:(DE-HGF)0$$aSchildan, Andreas$$b21
000902542 7001_ $$0P:(DE-HGF)0$$aPatt, Marianne$$b22
000902542 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b23
000902542 7001_ $$00000-0003-4247-184X$$aBarret, Olivier$$b24
000902542 7001_ $$0P:(DE-HGF)0$$aMadonia, Jennifer$$b25
000902542 7001_ $$00000-0002-9105-2943$$aRussell, David S$$b26
000902542 7001_ $$0P:(DE-HGF)0$$aStephens, Andrew W$$b27
000902542 7001_ $$0P:(DE-HGF)0$$aMueller, Andre$$b28
000902542 7001_ $$0P:(DE-HGF)0$$aRoeber, Sigrun$$b29
000902542 7001_ $$0P:(DE-HGF)0$$aHerms, Jochen$$b30
000902542 7001_ $$0P:(DE-HGF)0$$aBötzel, Kai$$b31
000902542 7001_ $$00000-0001-8857-5383$$aDanek, Adrian$$b32
000902542 7001_ $$0P:(DE-HGF)0$$aLevin, Johannes$$b33
000902542 7001_ $$0P:(DE-HGF)0$$aClassen, Joseph$$b34
000902542 7001_ $$0P:(DE-HGF)0$$aHöglinger, Günter U$$b35
000902542 7001_ $$0P:(DE-HGF)0$$aBartenstein, Peter$$b36
000902542 7001_ $$0P:(DE-HGF)0$$aVillemagne, Victor$$b37
000902542 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b38
000902542 7001_ $$0P:(DE-HGF)0$$aSeibyl, John$$b39
000902542 7001_ $$0P:(DE-HGF)0$$aSabri, Osama$$b40
000902542 7001_ $$0P:(DE-HGF)0$$aBoening, Guido$$b41
000902542 7001_ $$0P:(DE-HGF)0$$aZiegler, Sibylle$$b42
000902542 7001_ $$00000-0002-9247-2843$$aBrendel, Matthias$$b43$$eCorresponding author
000902542 773__ $$0PERI:(DE-600)2039456-1$$a10.1177/0271678X211018904$$gVol. 41, no. 11, p. 2957 - 2972$$n11$$p2957 - 2972$$tJournal of cerebral blood flow & metabolism$$v41$$x0271-678X$$y2021
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