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| 001 | 902542 | ||
| 005 | 20211130111100.0 | ||
| 024 | 7 | _ | |a 10.1177/0271678X211018904 |2 doi |
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| 024 | 7 | _ | |a 1559-7016 |2 ISSN |
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| 037 | _ | _ | |a FZJ-2021-04344 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Song, Mengmeng |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Binding characteristics of [ 18 F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET |
| 260 | _ | _ | |a London |c 2021 |b Sage |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1637227557_30969 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 520 | _ | _ | |a The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies. |
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| 700 | 1 | _ | |a Brendel, Matthias |0 0000-0002-9247-2843 |b 43 |e Corresponding author |
| 773 | _ | _ | |a 10.1177/0271678X211018904 |g Vol. 41, no. 11, p. 2957 - 2972 |0 PERI:(DE-600)2039456-1 |n 11 |p 2957 - 2972 |t Journal of cerebral blood flow & metabolism |v 41 |y 2021 |x 0271-678X |
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