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| Home > Publications database > Physiologic inspired channel design to study flow behavior of red blood cells |
| Poster (Invited) | FZJ-2021-04599 |
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2021
Please use a persistent id in citations: http://hdl.handle.net/2128/29218
Abstract: The blood flow dynamics through the micro-vascular system, which is the end of our vascular system, depends on many factors, such as the exact shape of the vessels, the aggregation and disaggregation and deformation of the red blood cells (RBCs) [1]. The blood flow has been studied for a long time. The field got a boost with the introduction of microfluidics, which allowed to study the effects of these parameters systematically, mostly using 2D channels with rectangular cross section, very different from the physiological vessels.The goal of this research project is to understand the interplay between aggregation, deformation and flow in model 3-D microfluidic channels as well as physiologically relevant shaped channels. We used a novel technique, Selective Laser-induced Etching (SLE), to produce 3D structures in glass. Here we present first results on the effect of bifurcations into different planes with any variable shape [2]. To study the shape memory of the vessels the second generation of the bifurcation has been implemented with a parallel and perpendicular orientation relative to the first bifurcation.
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