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000903477 1001_ $$0P:(DE-Juel1)161196$$aMenzel, Miriam$$b0$$eCorresponding author$$ufzj
000903477 245__ $$aScatterometry Measurements With Scattered Light Imaging Enable New Insights Into the Nerve Fiber Architecture of the Brain
000903477 260__ $$aLausanne$$bFrontiers Research Foundation$$c2021
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000903477 520__ $$aThe correct reconstruction of individual (crossing) nerve fibers is a prerequisite when constructing a detailed network model of the brain. The recently developed technique Scattered Light Imaging (SLI) allows the reconstruction of crossing nerve fiber pathways in whole brain tissue samples with micrometer resolution: the individual fiber orientations are determined by illuminating unstained histological brain sections from different directions, measuring the transmitted scattered light under normal incidence, and studying the light intensity profiles of each pixel in the resulting image series. So far, SLI measurements were performed with a fixed polar angle of illumination and a small number of illumination directions, providing only an estimate of the nerve fiber directions and limited information about the underlying tissue structure. Here, we use a display with individually controllable light-emitting diodes to measure the full distribution of scattered light behind the sample (scattering pattern) for each image pixel at once, enabling scatterometry measurements of whole brain tissue samples. We compare our results to coherent Fourier scatterometry (raster-scanning the sample with a non-focused laser beam) and previous SLI measurements with fixed polar angle of illumination, using sections from a vervet monkey brain and human optic tracts. Finally, we present SLI scatterometry measurements of a human brain section with 3 μm in-plane resolution, demonstrating that the technique is a powerful approach to gain new insights into the nerve fiber architecture of the human brain.
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000903477 536__ $$0G:(EU-Grant)945539$$aHBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539)$$c945539$$fH2020-SGA-FETFLAG-HBP-2019$$x2
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000903477 7001_ $$0P:(DE-Juel1)186038$$aRitzkowski, Marouan$$b1$$ufzj
000903477 7001_ $$0P:(DE-Juel1)167509$$aReuter, Jan A.$$b2$$ufzj
000903477 7001_ $$0P:(DE-Juel1)131642$$aGräßel, David$$b3$$ufzj
000903477 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b4$$ufzj
000903477 7001_ $$0P:(DE-Juel1)131632$$aAxer, Markus$$b5$$ufzj
000903477 773__ $$0PERI:(DE-600)2452969-2$$a10.3389/fnana.2021.767223$$gVol. 15, p. 767223$$p767223$$tFrontiers in neuroanatomy$$v15$$x1662-5129$$y2021
000903477 8564_ $$uhttps://juser.fz-juelich.de/record/903477/files/Menzel_etal_front.Neuroanatomy_2021.pdf$$yOpenAccess
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