% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Krugmann:903794,
      author       = {Krugmann, Benjamin and Koutsioumpas, Alexandros and Haris,
                      Luman and Micciulla, Samantha and Lairez, Didier and
                      Radulescu, Aurel and Förster, Stephan and Stadler, Andreas
                      M.},
      title        = {{A}dhesion {P}rocess of {B}iomimetic {M}yelin {M}embranes
                      {T}riggered by {M}yelin {B}asic {P}rotein},
      journal      = {Frontiers in Chemistry},
      volume       = {9},
      issn         = {2296-2646},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {FZJ-2021-05429},
      pages        = {631277},
      year         = {2021},
      abstract     = {The myelin sheath—a multi-double-bilayer membrane wrapped
                      around axons—is an essential part of the nervous system
                      which enables rapid signal conduction. Damage of this
                      complex membrane system results in demyelinating diseases
                      such as multiple sclerosis (MS). The process in which myelin
                      is generated in vivo is called myelination. In our study, we
                      investigated the adhesion process of large unilamellar
                      vesicles with a supported membrane bilayer that was coated
                      with myelin basic protein (MBP) using time-resolved neutron
                      reflectometry. Our aim was to mimic and to study the
                      myelination process of membrane systems having either a
                      lipid-composition resembling that of native myelin or that
                      of the standard animal model for experimental autoimmune
                      encephalomyelitis (EAE) which represents MS-like conditions.
                      We were able to measure the kinetics of the partial
                      formation of a double bilayer in those systems and to
                      characterize the scattering length density profiles of the
                      initial and final states of the membrane. The kinetics could
                      be modeled using a random sequential adsorption simulation.
                      By using a free energy minimization method, we were able to
                      calculate the shape of the adhered vesicles and to determine
                      the adhesion energy per MBP. For the native membrane the
                      resulting adhesion energy per MBP is larger than that of the
                      EAE modified membrane type. Our observations might help in
                      understanding myelination and especially remyelination—a
                      process in which damaged myelin is repaired—which is a
                      promising candidate for treatment of the still mostly
                      incurable demyelinating diseases such as MS.},
      cin          = {JCNS-1 / JCNS-4 / JCNS-FRM-II / MLZ / IBI-8},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-4-20201012 /
                      I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)IBI-8-20200312},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4) / 632 - Materials – Quantum, Complex and
                      Functional Materials (POF4-632)},
      pid          = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
      experiment   = {EXP:(DE-MLZ)MARIA-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34017815},
      UT           = {WOS:000651217900001},
      doi          = {10.3389/fchem.2021.631277},
      url          = {https://juser.fz-juelich.de/record/903794},
}