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@ARTICLE{Bopp:904290,
      author       = {Bopp, Sandra K and Heilbronner, Urs and Schlattmann, Peter
                      and Buspavanich, Pichit J and Lang, Undine E and Heinz,
                      Andreas and Schulze, Thomas G and Adli, Mazda and
                      Mühleisen, Thomas W and Ricken, Roland},
      title        = {{A} {GWAS} top hit for circulating leptin is associated
                      with weight gain but not with leptin protein levels in
                      lithium-augmented patients with major depression},
      journal      = {European neuropsychopharmacology},
      volume       = {53},
      issn         = {0924-977X},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2021-05860},
      pages        = {114 - 119},
      year         = {2021},
      abstract     = {Lithium-treated patients often suffer from weight gain as a
                      common adverse event. In an earlier investigation, we found
                      an impact of two single-nucleotide polymorphisms (rs10487506
                      and rs2278815) at the leptin gene on weight gain but not on
                      leptin protein levels in serum under lithium augmentation. A
                      recent genome-wide association study identified a
                      polymorphism at the leptin gene locus (rs10487505)
                      associated with circulating leptin protein levels. To
                      characterize potential effects of this variant in acute
                      major depressive disorder, we investigated body mass indices
                      from 180 lithium-augmented patients and serum concentrations
                      of leptin protein from 89 patients using linear mixed model
                      analyses and rs6979832, a proxy SNP of rs10487505. Body mass
                      index was measured before and after 4 weeks of lithium
                      augmentation, in a subsample also after 4 and 7 months.
                      Leptin serum levels were measured before and during lithium
                      augmentation. G-allele homozygotes of rs6979832 had a
                      significantly lower body mass index increase during
                      observation compared to A-allele hetero- and homozygotes.
                      However, we found no influence on leptin serum levels. Joint
                      analyses of rs6979832 with the previously investigated
                      polymorphisms rs10487506 and rs2278815, and expressed
                      quantitative trait data, suggest a complex interplay between
                      SNP alleles at the leptin locus. These results strongly
                      support our earlier findings that common genetic variation
                      at the leptin gene locus may be involved in lithium
                      augmentation-associated weight gain in major depressive
                      disorder.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34653833},
      UT           = {WOS:000710068400001},
      doi          = {10.1016/j.euroneuro.2021.09.007},
      url          = {https://juser.fz-juelich.de/record/904290},
}