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@ARTICLE{Bopp:904290,
author = {Bopp, Sandra K and Heilbronner, Urs and Schlattmann, Peter
and Buspavanich, Pichit J and Lang, Undine E and Heinz,
Andreas and Schulze, Thomas G and Adli, Mazda and
Mühleisen, Thomas W and Ricken, Roland},
title = {{A} {GWAS} top hit for circulating leptin is associated
with weight gain but not with leptin protein levels in
lithium-augmented patients with major depression},
journal = {European neuropsychopharmacology},
volume = {53},
issn = {0924-977X},
address = {Amsterdam},
publisher = {Elsevier},
reportid = {FZJ-2021-05860},
pages = {114 - 119},
year = {2021},
abstract = {Lithium-treated patients often suffer from weight gain as a
common adverse event. In an earlier investigation, we found
an impact of two single-nucleotide polymorphisms (rs10487506
and rs2278815) at the leptin gene on weight gain but not on
leptin protein levels in serum under lithium augmentation. A
recent genome-wide association study identified a
polymorphism at the leptin gene locus (rs10487505)
associated with circulating leptin protein levels. To
characterize potential effects of this variant in acute
major depressive disorder, we investigated body mass indices
from 180 lithium-augmented patients and serum concentrations
of leptin protein from 89 patients using linear mixed model
analyses and rs6979832, a proxy SNP of rs10487505. Body mass
index was measured before and after 4 weeks of lithium
augmentation, in a subsample also after 4 and 7 months.
Leptin serum levels were measured before and during lithium
augmentation. G-allele homozygotes of rs6979832 had a
significantly lower body mass index increase during
observation compared to A-allele hetero- and homozygotes.
However, we found no influence on leptin serum levels. Joint
analyses of rs6979832 with the previously investigated
polymorphisms rs10487506 and rs2278815, and expressed
quantitative trait data, suggest a complex interplay between
SNP alleles at the leptin locus. These results strongly
support our earlier findings that common genetic variation
at the leptin gene locus may be involved in lithium
augmentation-associated weight gain in major depressive
disorder.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34653833},
UT = {WOS:000710068400001},
doi = {10.1016/j.euroneuro.2021.09.007},
url = {https://juser.fz-juelich.de/record/904290},
}