TY  - JOUR
AU  - Ariantari, Ni Putu
AU  - Frank, Marian
AU  - Gao, Ying
AU  - Stuhldreier, Fabian
AU  - Kiffe-Delf, Anna-Lene
AU  - Hartmann, Rudolf
AU  - Höfert, Simon-Patrick
AU  - Janiak, Christoph
AU  - Wesselborg, Sebastian
AU  - Müller, Werner E. G.
AU  - Kalscheuer, Rainer
AU  - Liu, Zhen
AU  - Proksch, Peter
TI  - Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense
JO  - Tetrahedron
VL  - 85
SN  - 0040-4020
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2021-05873
SP  - 132065 -
PY  - 2021
N1  - Kein Post-print vorhanden
AB  - Three new lipodepsipeptides, fusaristatins DeF ( 1e3) and a new a-pyrone derivative, (7S,8R)-()-chlamydospordiol (5), together with eight known compounds (4, 6e12) were obtained from solidrice cultures of Fusarium sp. BZCB-CA, an endophyte of the Chinese medicinal plant, Bothriospermumchinense. The planar structures of the new metabolites (1e3, 5) were established by spectroscopictechniques (1D/2D NMR and HRESIMS). Marfey’s method was applied to determine the absoluteconfiguration of 1, while the absolute configuration of 5 was determined by single-crystal X-ray crys-tallography analysis in addition to Mosher’s method. Crystallographic data of inflatin C (7) are alsosupplied here for the first time. In cytotoxicity assays, rubrofusarin (8) showed a moderate effect on thelymphoma cell lines L5178Y, Ramos and Jurkat, with IC50 values of 7.7, 6.2 and 6.3 mM, respectively, whilethe remaining compounds were inactive. When subjected to antibacterial assay, only lateropyrone (9)exhibited good to weak activity against a panel of Gram-positive bacteria including drug-resistant strainswith MICs ranging from 3.1 to 25 mM.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000634925100023
DO  - DOI:10.1016/j.tet.2021.132065
UR  - https://juser.fz-juelich.de/record/904303
ER  -