Journal Article

FZJ-2021-05873

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense

Ariantari, N. P. ; Frank, M. ; Gao, Y. ; Stuhldreier, F. ; Kiffe-Delf, A.-L. ; Hartmann, R.FZJ* ; Höfert, S.-P. ; Janiak, C. ; Wesselborg, S. ; Müller, W. E. G. ; Kalscheuer, R. ; Liu, Z. (Corresponding author) ; Proksch, P. (Corresponding author)

2021
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.tet.2021.132065

Abstract: Three new lipodepsipeptides, fusaristatins DeF ( 1e3) and a new a-pyrone derivative, (7S,8R)-()-chlamydospordiol (5), together with eight known compounds (4, 6e12) were obtained from solidrice cultures of Fusarium sp. BZCB-CA, an endophyte of the Chinese medicinal plant, Bothriospermumchinense. The planar structures of the new metabolites (1e3, 5) were established by spectroscopictechniques (1D/2D NMR and HRESIMS). Marfey’s method was applied to determine the absoluteconfiguration of 1, while the absolute configuration of 5 was determined by single-crystal X-ray crys-tallography analysis in addition to Mosher’s method. Crystallographic data of inflatin C (7) are alsosupplied here for the first time. In cytotoxicity assays, rubrofusarin (8) showed a moderate effect on thelymphoma cell lines L5178Y, Ramos and Jurkat, with IC50 values of 7.7, 6.2 and 6.3 mM, respectively, whilethe remaining compounds were inactive. When subjected to antibacterial assay, only lateropyrone (9)exhibited good to weak activity against a panel of Gram-positive bacteria including drug-resistant strainswith MICs ranging from 3.1 to 25 mM.

Note: Kein Post-print vorhanden

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; Index Chemicus ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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