%0 Journal Article
%A Sorokina, Oksana
%A Mclean, Colin
%A Croning, Mike D. R.
%A Heil, Katharina F.
%A Wysocka, Emilia
%A He, Xin
%A Sterratt, David
%A Grant, Seth G. N.
%A Simpson, T. Ian
%A Armstrong, J. Douglas
%T A unified resource and configurable model of the synapse proteome and its role in disease
%J Scientific reports
%V 11
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M FZJ-2021-06129
%P 9967
%D 2021
%X Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33976238
%U <Go to ISI:>//WOS:000658810700001
%R 10.1038/s41598-021-88945-7
%U https://juser.fz-juelich.de/record/904559