Journal Article

FZJ-2021-06129

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A unified resource and configurable model of the synapse proteome and its role in disease

Sorokina, O. (Corresponding author)Extern* ; Mclean, C. (Corresponding author)Extern* ; Croning, M. D. R.Extern* ; Heil, K. F.Extern* ; Wysocka, E.Extern* ; He, X.Extern* ; Sterratt, D.Extern* ; Grant, S. G. N.Extern* ; Simpson, T. I.Extern* ; Armstrong, J. D.FZJ*

2021
Macmillan Publishers Limited, part of Springer Nature [London]

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Please use a persistent id in citations: http://hdl.handle.net/2128/30617  doi:10.1038/s41598-021-88945-7

Abstract: Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.

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Contributing Institute(s):

1. Computational Biomedicine (IAS-5)
2. Computational Biomedicine (INM-9)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2021

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