TY  - JOUR
AU  - Liebl, Maik
AU  - Eberbeck, Dietmar
AU  - Coene, Annelies
AU  - Leliaert, Jonathan
AU  - Jauch, Philine
AU  - Kruteva, Margarita
AU  - Fruhner, Lisa
AU  - Barnsley, Lester
AU  - Mayr, Stefan G.
AU  - Wiekhorst, Frank
TI  - Magnetic measurement methods to probe nanoparticle–matrix interactions
JO  - Physical sciences reviews
VL  - 0
IS  - 0
SN  - 2365-659X
CY  - Berlin
PB  - de Gruyter
M1  - FZJ-2022-00026
SP  - 20190112
PY  - 2021
AB  - Magnetic nanoparticles (MNPs) are key elements in several biomedicalapplications, e.g., in cancer therapy. Here, the MNPs are remotely manipulated bymagnetic fields from outside the body to deliver drugs or generate heat in tumor tissue.The efficiency and success of these approaches strongly depend on the spatial distri-bution and quantity of MNPs inside a body and interactions of the particles with thebiological matrix. These include dynamic processes of the MNPs in the organism suchas binding kinetics, cellular uptake, passage through cell barriers, heat induction andflow. While magnetic measurement methods have been applied so far to resolve thelocation and quantity of MNPs for therapy monitoring, these methods can be advancedto additionally access these particle–matrix interactions. By this, the MNPs can furtherbe utilized as probes for the physical properties of their molecular environment. In thisreview, we first investigate the impact of nanoparticle–matrix interactions on magneticmeasurements in selected experiments. With these results, we then advanced theimaging modalities magnetorelaxometry imaging and magnetic microsphere trackingto spatially resolve particle–matrix interactions.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000868784100003
DO  - DOI:10.1515/psr-2019-0112
UR  - https://juser.fz-juelich.de/record/904677
ER  -