Journal Article

FZJ-2022-00026

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Magnetic measurement methods to probe nanoparticle–matrix interactions

Liebl, M. (Corresponding author) ; Eberbeck, D. ; Coene, A. ; Leliaert, J. ; Jauch, P. ; Kruteva, M.FZJ* ; Fruhner, L.FZJ* ; Barnsley, L. ; Mayr, S. G. ; Wiekhorst, F.

2021
de Gruyter Berlin

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Please use a persistent id in citations: http://hdl.handle.net/2128/30781  doi:10.1515/psr-2019-0112

Abstract: Magnetic nanoparticles (MNPs) are key elements in several biomedicalapplications, e.g., in cancer therapy. Here, the MNPs are remotely manipulated bymagnetic fields from outside the body to deliver drugs or generate heat in tumor tissue.The efficiency and success of these approaches strongly depend on the spatial distri-bution and quantity of MNPs inside a body and interactions of the particles with thebiological matrix. These include dynamic processes of the MNPs in the organism suchas binding kinetics, cellular uptake, passage through cell barriers, heat induction andflow. While magnetic measurement methods have been applied so far to resolve thelocation and quantity of MNPs for therapy monitoring, these methods can be advancedto additionally access these particle–matrix interactions. By this, the MNPs can furtherbe utilized as probes for the physical properties of their molecular environment. In thisreview, we first investigate the impact of nanoparticle–matrix interactions on magneticmeasurements in selected experiments. With these results, we then advanced theimaging modalities magnetorelaxometry imaging and magnetic microsphere trackingto spatially resolve particle–matrix interactions.

Keyword(s): Polymers, Soft Nano Particles and Proteins (1st) ; Soft Condensed Matter (2nd)

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Contributing Institute(s):

1. Neutronenstreuung (JCNS-1)
2. Heinz Maier-Leibnitz Zentrum (MLZ)
3. JCNS-FRM-II (JCNS-FRM-II)
4. JCNS-4 (JCNS-4)

Research Program(s):

1. 6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ) (POF4-6G4) (POF4-6G4)
2. 632 - Materials – Quantum, Complex and Functional Materials (POF4-632) (POF4-632)

Experiment(s):

1. KWS-1: Small angle scattering diffractometer (NL3b)

Appears in the scientific report 2022

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Emerging Sources Citation Index ; SCOPUS ; Web of Science Core Collection

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