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@ARTICLE{Liebl:904677,
      author       = {Liebl, Maik and Eberbeck, Dietmar and Coene, Annelies and
                      Leliaert, Jonathan and Jauch, Philine and Kruteva, Margarita
                      and Fruhner, Lisa and Barnsley, Lester and Mayr, Stefan G.
                      and Wiekhorst, Frank},
      title        = {{M}agnetic measurement methods to probe
                      nanoparticle–matrix interactions},
      journal      = {Physical sciences reviews},
      volume       = {0},
      number       = {0},
      issn         = {2365-659X},
      address      = {Berlin},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2022-00026},
      pages        = {20190112},
      year         = {2021},
      abstract     = {Magnetic nanoparticles (MNPs) are key elements in several
                      biomedicalapplications, e.g., in cancer therapy. Here, the
                      MNPs are remotely manipulated bymagnetic fields from outside
                      the body to deliver drugs or generate heat in tumor
                      tissue.The efficiency and success of these approaches
                      strongly depend on the spatial distri-bution and quantity of
                      MNPs inside a body and interactions of the particles with
                      thebiological matrix. These include dynamic processes of the
                      MNPs in the organism suchas binding kinetics, cellular
                      uptake, passage through cell barriers, heat induction
                      andflow. While magnetic measurement methods have been
                      applied so far to resolve thelocation and quantity of MNPs
                      for therapy monitoring, these methods can be advancedto
                      additionally access these particle–matrix interactions. By
                      this, the MNPs can furtherbe utilized as probes for the
                      physical properties of their molecular environment. In
                      thisreview, we first investigate the impact of
                      nanoparticle–matrix interactions on magneticmeasurements
                      in selected experiments. With these results, we then
                      advanced theimaging modalities magnetorelaxometry imaging
                      and magnetic microsphere trackingto spatially resolve
                      particle–matrix interactions.},
      cin          = {JCNS-1 / MLZ / JCNS-FRM-II / JCNS-4},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-4-20201012},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4) / 632 - Materials – Quantum, Complex and
                      Functional Materials (POF4-632)},
      pid          = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000868784100003},
      doi          = {10.1515/psr-2019-0112},
      url          = {https://juser.fz-juelich.de/record/904677},
}