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@ARTICLE{Bethlehem:905771,
author = {Bethlehem, Richard AI and Seidlitz, Jakob and White, Simon
R and Vogel, Jacob W and Anderson, Kevin M and Adamson,
Chris and Adler, Sophie and Alexopoulos, George S and
Anagnostou, Evdokia and Areces-Gonzalez, Ariosky and Astle,
Duncan E and Auyeung, Bonnie and Ayub, Muhammad and Ball,
Gareth and Baron-Cohen, Simon and Beare, Richard and
Bedford, Saashi A and Benegal, Vivek and Beyer, Frauke and
Bae, Jong Bin and Blangero, John and Cabez, Manuel Blesa and
Boardman, James P and Borzage, Matthew and Bosch-Bayard,
Jorge F and Bourke, Niall and Calhoun, Vince D and
Chakravarty, Mallar M and Chen, Christina and Chertavian,
Casey and Chetelat, Gael and Chong, Yap S and Cole, James H
and Corvin, Aiden and Courchesne, Eric and Crivello, Fabrice
and Cropley, Vanessa L and Crosbie, Jennifer and Crossley,
Nicolas and Delarue, Marion and Desrivieres, Sylvane and
Devenyi, Gabriel and Biase, Maria A Di and Dolan, Ray and
Donald, Kirsten A and Donohoe, Gary and Dunlop, Katharine
and Edwards, Anthony D and Elison, Jed T and Ellis, Cameron
T and Elman, Jeremy A and Eyler, Lisa and Fair, Damien A and
Fletcher, Paul C and Fonagy, Peter and Franz, Carol E and
Galan-Garcia, Lidice and Gholipour, Ali and Giedd, Jay and
Gilmore, John H and Glahn, David C and Goodyer, Ian and
Grant, PE and Groenewold, Nynke A and Gunning, Faith M and
Gur, Raquel E and Gur, Ruben C and Hammill, Christopher F
and Hansson, Oskar and Hedden, Trey and Heinz, Andreas and
Henson, Richard and Heuer, Katja and Hoare, Jacqueline and
Holla, Bharath and Holmes, Avram J and Holt, Rosie and
Huang, Hao and Im, Kiho and Ipser, Jonathan and Jack,
Clifford R and Jackowski, Andrea P and Jia, Tianye and
Johnson, Keith A and Jones, David T and Jones, Peter B and
Kahn, Rene and Karlsson, Hasse and Karlsson, Linnea and
Kawashima, Ryuta and Kelley, Elizabeth A and Kern, Silke and
Kim, KW and Kitzbichler, Manfred G and Kremen, William S and
Lalonde, Francois and Landeau, Brigitte and Lee, Subin and
Lerch, Jason and Lewis, John D and Li, Jiao and Liao, Wei
and Linares, Deirel P and Liston, Conor and Lombardo,
Michael V and Lv, Jinglei and Lynch, Charles and Mallard,
Travis T and Marcelis, Machteld and Markello, Ross D and
Mazoyer, Bernard and McGuire, Philip and Meaney, Michael J
and Mechelli, Andrea and Medic, Nenad and Misic, Bratislav
and Morgan, Sarah E and Mothersill, David and Nigg, Joel and
Ong, Marcus QW and Ortinau, Cynthia and Ossenkoppele, Rik
and Ouyang, Minhui and Palaniyappan, Lena and Paly, Leo and
Pan, Pedro M and Pantelis, Christos and Park, Min Tae M and
Paus, Tomas and Pausova, Zdenka and Binette, Alexa Pichet
and Pierce, Karen and Qian, Xing and Qiu, Anqi and Qiu,
Jiang and Raznahan, Armin and Rittman, Timothy and Rollins,
Caitlin K and Romero-Garcia, Rafael and Ronan, Lisa and
Rosenberg, Monica D and Rowitch, David H and Salum, Giovanni
A and Satterthwaite, Theodore D and Schaare, Lina and
Schachar, Russell J and Scholl, Michael and Schultz, Aaron P
and Schumann, Gunter and Sharp, David},
title = {{B}raincharts for the human lifespan},
reportid = {FZJ-2022-00994},
year = {2021},
abstract = {Over the past 25 years, neuroimaging has become a
ubiquitous tool in basic research and clinical studies of
the human brain. However, there are no reference standards
against which to anchor measures of individual differences
in brain morphology, in contrast to growth charts for traits
such as height and weight. Here, we built an interactive
online resource (www.brainchart.io) to quantify individual
differences in brain structure from any current or future
magnetic resonance imaging (MRI) study, against models of
expected age-related trends. With the goal of basing these
on the largest and most inclusive dataset, we aggregated MRI
data spanning 115 days post-conception through 100 postnatal
years, totaling 122,123 scans from 100,071 individuals in
over 100 studies across 6 continents. When quantified as
centile scores relative to the reference models, individual
differences show high validity with non-MRI brain growth
estimates and high stability across longitudinal assessment.
Centile scores helped identify previously unreported brain
developmental milestones and demonstrated increased genetic
heritability compared to non-centiled MRI phenotypes.
Crucially for the study of brain disorders, centile scores
provide a standardised and interpretable measure of
deviation that reveals new patterns of neuroanatomical
differences across neurological and psychiatric disorders
emerging during development and ageing. In sum, brain charts
for the human lifespan are an essential first step towards
robust, standardised quantification of individual variation
and for characterizing deviation from age-related trends.
Our global collaborative study …},
cin = {INM-7},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)25},
url = {https://juser.fz-juelich.de/record/905771},
}
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