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000906621 1001_ $$0P:(DE-HGF)0$$aYin, Shelly$$b0$$eFirst author
000906621 245__ $$aShared and Distinct Patterns of Atypical Cortical Morphometry in Children with Autism and Anxiety
000906621 260__ $$aOxford$$bOxford Univ. Press$$c2022
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000906621 520__ $$aAutism spectrum disorder (ASD) and anxiety disorders (ANX) are common neurodevelopmental conditions with several overlapping symptoms. Notably, many children and adolescents with ASD also have an ANX diagnosis, suggesting shared pathological mechanisms. Here, we leveraged structural imaging and phenotypic data from 112 youth (33 ASD, 37 ANX, 42 typically developing controls) to assess shared and distinct cortical thickness patterns of the disorders. ANX was associated with widespread increases in cortical thickness, while ASD related to a mixed pattern of subtle increases and decreases across the cortical mantle. Despite the qualitative difference in the case–control contrasts, the statistical maps from the ANX-vs-controls and ASD-vs-controls analyses were significantly correlated when correcting for spatial autocorrelation. Dimensional analysis, regressing trait anxiety and social responsiveness against cortical thickness measures, partially recapitulated diagnosis-based findings. Collectively, our findings provide evidence for a common axis of neurodevelopmental disturbances as well as distinct effects of ASD and ANX on cortical thickness.
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000906621 7001_ $$0P:(DE-HGF)0$$aHong, Seok-Jun$$b1
000906621 7001_ $$0P:(DE-HGF)0$$aDi Martino, Adriana$$b2
000906621 7001_ $$0P:(DE-HGF)0$$aMilham, Michael P$$b3
000906621 7001_ $$0P:(DE-HGF)0$$aPark, Bo-Yong$$b4
000906621 7001_ $$0P:(DE-HGF)0$$aBenkarim, Oualid$$b5
000906621 7001_ $$0P:(DE-HGF)0$$aBethlehem, Richard A I$$b6
000906621 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C$$b7
000906621 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b8$$eCorresponding author
000906621 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhab502$$gp. bhab502$$n20$$p4565–4575$$tCerebral cortex$$v23$$x1047-3211$$y2022
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