Journal Article

FZJ-2022-01557

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Shared and Distinct Patterns of Atypical Cortical Morphometry in Children with Autism and Anxiety

Yin, S. (First author) ; Hong, S.-J. ; Di Martino, A. ; Milham, M. P. ; Park, B.-Y. ; Benkarim, O. ; Bethlehem, R. A. I. ; Bernhardt, B. C. ; Paquola, C. (Corresponding author)FZJ*

2022
Oxford Univ. Press Oxford

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Please use a persistent id in citations: http://hdl.handle.net/2128/32898  doi:10.1093/cercor/bhab502

Abstract: Autism spectrum disorder (ASD) and anxiety disorders (ANX) are common neurodevelopmental conditions with several overlapping symptoms. Notably, many children and adolescents with ASD also have an ANX diagnosis, suggesting shared pathological mechanisms. Here, we leveraged structural imaging and phenotypic data from 112 youth (33 ASD, 37 ANX, 42 typically developing controls) to assess shared and distinct cortical thickness patterns of the disorders. ANX was associated with widespread increases in cortical thickness, while ASD related to a mixed pattern of subtle increases and decreases across the cortical mantle. Despite the qualitative difference in the case–control contrasts, the statistical maps from the ANX-vs-controls and ASD-vs-controls analyses were significantly correlated when correcting for spatial autocorrelation. Dimensional analysis, regressing trait anxiety and social responsiveness against cortical thickness measures, partially recapitulated diagnosis-based findings. Collectively, our findings provide evidence for a common axis of neurodevelopmental disturbances as well as distinct effects of ASD and ANX on cortical thickness.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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