TY  - JOUR
AU  - Yin, Shelly
AU  - Hong, Seok-Jun
AU  - Di Martino, Adriana
AU  - Milham, Michael P
AU  - Park, Bo-Yong
AU  - Benkarim, Oualid
AU  - Bethlehem, Richard A I
AU  - Bernhardt, Boris C
AU  - Paquola, Casey
TI  - Shared and Distinct Patterns of Atypical Cortical Morphometry in Children with Autism and Anxiety
JO  - Cerebral cortex
VL  - 23
IS  - 20
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2022-01557
SP  - 4565–4575
PY  - 2022
AB  - Autism spectrum disorder (ASD) and anxiety disorders (ANX) are common neurodevelopmental conditions with several overlapping symptoms. Notably, many children and adolescents with ASD also have an ANX diagnosis, suggesting shared pathological mechanisms. Here, we leveraged structural imaging and phenotypic data from 112 youth (33 ASD, 37 ANX, 42 typically developing controls) to assess shared and distinct cortical thickness patterns of the disorders. ANX was associated with widespread increases in cortical thickness, while ASD related to a mixed pattern of subtle increases and decreases across the cortical mantle. Despite the qualitative difference in the case–control contrasts, the statistical maps from the ANX-vs-controls and ASD-vs-controls analyses were significantly correlated when correcting for spatial autocorrelation. Dimensional analysis, regressing trait anxiety and social responsiveness against cortical thickness measures, partially recapitulated diagnosis-based findings. Collectively, our findings provide evidence for a common axis of neurodevelopmental disturbances as well as distinct effects of ASD and ANX on cortical thickness.
LB  - PUB:(DE-HGF)16
C6  - 35059701
UR  - <Go to ISI:>//WOS:000868822700012
DO  - DOI:10.1093/cercor/bhab502
UR  - https://juser.fz-juelich.de/record/906621
ER  -