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@ARTICLE{Yin:906621,
      author       = {Yin, Shelly and Hong, Seok-Jun and Di Martino, Adriana and
                      Milham, Michael P and Park, Bo-Yong and Benkarim, Oualid and
                      Bethlehem, Richard A I and Bernhardt, Boris C and Paquola,
                      Casey},
      title        = {{S}hared and {D}istinct {P}atterns of {A}typical {C}ortical
                      {M}orphometry in {C}hildren with {A}utism and {A}nxiety},
      journal      = {Cerebral cortex},
      volume       = {23},
      number       = {20},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-01557},
      pages        = {4565–4575},
      year         = {2022},
      abstract     = {Autism spectrum disorder (ASD) and anxiety disorders (ANX)
                      are common neurodevelopmental conditions with several
                      overlapping symptoms. Notably, many children and adolescents
                      with ASD also have an ANX diagnosis, suggesting shared
                      pathological mechanisms. Here, we leveraged structural
                      imaging and phenotypic data from 112 youth (33 ASD, 37 ANX,
                      42 typically developing controls) to assess shared and
                      distinct cortical thickness patterns of the disorders. ANX
                      was associated with widespread increases in cortical
                      thickness, while ASD related to a mixed pattern of subtle
                      increases and decreases across the cortical mantle. Despite
                      the qualitative difference in the case–control contrasts,
                      the statistical maps from the ANX-vs-controls and
                      ASD-vs-controls analyses were significantly correlated when
                      correcting for spatial autocorrelation. Dimensional
                      analysis, regressing trait anxiety and social responsiveness
                      against cortical thickness measures, partially recapitulated
                      diagnosis-based findings. Collectively, our findings provide
                      evidence for a common axis of neurodevelopmental
                      disturbances as well as distinct effects of ASD and ANX on
                      cortical thickness.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35059701},
      UT           = {WOS:000868822700012},
      doi          = {10.1093/cercor/bhab502},
      url          = {https://juser.fz-juelich.de/record/906621},
}