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@ARTICLE{Hensel:907508,
      author       = {Hensel, Lukas and Lange, Fabian and Tscherpel, Caroline and
                      Viswanathan, Shivakumar and Freytag, Jana and Eickhoff,
                      Simon and Volz, Lukas J. and Fink, Gereon Rudolf and
                      Grefkes, Christian},
      title        = {{R}ecovered grasping performance after stroke depends on
                      interhemispheric frontoparietal connectivity},
      journal      = {Brain},
      volume       = {146},
      number       = {3},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-02063},
      pages        = {1006-1020},
      year         = {2023},
      abstract     = {Activity changes in the ipsi- and contralesional parietal
                      cortex and abnormal interhemispheric connectivity between
                      these regions are commonly observed after stroke, however,
                      their significance for motor recovery remains poorly
                      understood. We here assessed the contribution of
                      ipsilesional and contralesional anterior intraparietal
                      cortex (aIPS) for hand motor function in eighteen recovered
                      chronic stroke patients and eighteen healthy controls using
                      a multimodal assessment consisting of resting-state fMRI,
                      motor task fMRI, online-rTMS interference, and 3-D movement
                      kinematics. Effects were compared against two control
                      stimulation sites, i.e., contralesional M1 and a sham
                      stimulation condition. We found that patients with good
                      motor outcome compared to patients with more substantial
                      residual deficits featured increased resting-state
                      connectivity between ipsilesional aIPS and contralesional
                      aIPS as well as between ipsilesional aIPS and dorsal
                      premotor cortex. Moreover, interhemispheric connectivity
                      between ipsilesional M1 and contralesional M1 as well as
                      ipsilesional aIPS and contralesional M1 correlated with
                      better motor performance across tasks. TMS interference at
                      individual aIPS and M1 coordinates led to differential
                      effects depending on the motor task that was tested, i.e.,
                      index finger-tapping, rapid pointing movements, or a
                      reach-grasp-lift task. Interfering with contralesional aIPS
                      deteriorated the accuracy of grasping, especially in
                      patients featuring higher connectivity between ipsi- and
                      contralesional aIPS. In contrast, interference with the
                      contralesional M1 led to impaired grasping speed in patients
                      featuring higher connectivity between bilateral M1. These
                      findings suggest differential roles of contralesional M1 and
                      aIPS for distinct aspects of recovered hand motor function,
                      depending on the reorganization of interhemispheric
                      connectivity.},
      cin          = {INM-7 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project 431549029 - SFB 1451: Schlüsselmechanismen normaler
                      und krankheitsbedingt gestörter motorischer Kontrolle
                      (431549029)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35485480},
      UT           = {WOS:000894006500001},
      doi          = {10.1093/brain/awac157},
      url          = {https://juser.fz-juelich.de/record/907508},
}