Journal Article

FZJ-2022-02063

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Recovered grasping performance after stroke depends on interhemispheric frontoparietal connectivity

Hensel, L. ; Lange, F. ; Tscherpel, C. ; Viswanathan, S.FZJ* ; Freytag, J. ; Eickhoff, S.FZJ* ; Volz, L. J. ; Fink, G. R.FZJ* ; Grefkes, C. (Corresponding author)FZJ*

2023
Oxford Univ. Press Oxford

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Please use a persistent id in citations: http://hdl.handle.net/2128/34152  doi:10.1093/brain/awac157

Abstract: Activity changes in the ipsi- and contralesional parietal cortex and abnormal interhemispheric connectivity between these regions are commonly observed after stroke, however, their significance for motor recovery remains poorly understood. We here assessed the contribution of ipsilesional and contralesional anterior intraparietal cortex (aIPS) for hand motor function in eighteen recovered chronic stroke patients and eighteen healthy controls using a multimodal assessment consisting of resting-state fMRI, motor task fMRI, online-rTMS interference, and 3-D movement kinematics. Effects were compared against two control stimulation sites, i.e., contralesional M1 and a sham stimulation condition. We found that patients with good motor outcome compared to patients with more substantial residual deficits featured increased resting-state connectivity between ipsilesional aIPS and contralesional aIPS as well as between ipsilesional aIPS and dorsal premotor cortex. Moreover, interhemispheric connectivity between ipsilesional M1 and contralesional M1 as well as ipsilesional aIPS and contralesional M1 correlated with better motor performance across tasks. TMS interference at individual aIPS and M1 coordinates led to differential effects depending on the motor task that was tested, i.e., index finger-tapping, rapid pointing movements, or a reach-grasp-lift task. Interfering with contralesional aIPS deteriorated the accuracy of grasping, especially in patients featuring higher connectivity between ipsi- and contralesional aIPS. In contrast, interference with the contralesional M1 led to impaired grasping speed in patients featuring higher connectivity between bilateral M1. These findings suggest differential roles of contralesional M1 and aIPS for distinct aspects of recovered hand motor function, depending on the reorganization of interhemispheric connectivity.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)
2. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
2. DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)

Appears in the scientific report 2023

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; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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