TY  - JOUR
AU  - Oros-Peusquens, A.M.
AU  - Stoecker, T.
AU  - Amunts, K.
AU  - Zilles, K.
AU  - Shah, J. N.
TI  - In vivo imaging of the human brain at 1.5 T with 0,6-mm isotropic resolution
JO  - Magnetic resonance imaging
VL  - 28
SN  - 0730-725X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-9077
SP  - 329 - 340
PY  - 2010
N1  - We are grateful to the volunteers for their collaboration. The MRI facility is supported by the Bundesministerium far Bildung und Forschung (BMBF) through a grant (BMBF 01GO0104) to N.J.S. and K.Z. This Human Brain Project/Neuroinformatics research is funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health. The support of the BMBF (Brain Imaging Centre West BMBF, 01GO0204) is kindly acknowledged.
AB  - We present high-resolution in vivo anatomical scans with 3D whole-brain coverage and an isotropic resolution of 0.6 mm, obtained at a clinical field of 1.5 T. The data are acquired in 10 independent scans over two sessions using a 3D magnetization-prepared, gradient echo sequence, modified to output phase images in addition to magnitude images. The independent scans are coregistered to correct for head motion, prior to performing complex averaging. The resolution of the final, averaged image, is found to be equal to the nominal one. The separation between the distribution of gray-scale values characterizing the gray and white matter, respectively, is substantially improved over single-scan images. Complex and magnitude averaging are compared and found to deliver similar results for regions with a high initial signal-to-noise ratio (SNR) within the brain. However, complex averaging is strongly recommended for quantitative applications or for studies where regions of low initial SNR are important. To summarize, a method for high-resolution in vivo anatomical imaging at a clinical field strength is demonstrated and is recommended for brain mapping. The method can also be applied at higher fields with a reduced acquisition time.
KW  - Adult
KW  - Algorithms
KW  - Anisotropy
KW  - Female
KW  - Humans
KW  - Image Enhancement: methods
KW  - Image Interpretation, Computer-Assisted: methods
KW  - Imaging, Three-Dimensional: methods
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Reproducibility of Results
KW  - Sensitivity and Specificity
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20117896
UR  - <Go to ISI:>//WOS:000276042400004
DO  - DOI:10.1016/j.mri.2009.11.006
UR  - https://juser.fz-juelich.de/record/9077
ER  -