Journal Article

PreJuSER-9077

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png In vivo imaging of the human brain at 1.5 T with 0,6-mm isotropic resolution

Oros-Peusquens, A. M.FZJ* ; Stoecker, T.FZJ* ; Amunts, K.FZJ* ; Zilles, K.FZJ* ; Shah, J. N.FZJ*

2010
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.mri.2009.11.006

Abstract: We present high-resolution in vivo anatomical scans with 3D whole-brain coverage and an isotropic resolution of 0.6 mm, obtained at a clinical field of 1.5 T. The data are acquired in 10 independent scans over two sessions using a 3D magnetization-prepared, gradient echo sequence, modified to output phase images in addition to magnitude images. The independent scans are coregistered to correct for head motion, prior to performing complex averaging. The resolution of the final, averaged image, is found to be equal to the nominal one. The separation between the distribution of gray-scale values characterizing the gray and white matter, respectively, is substantially improved over single-scan images. Complex and magnitude averaging are compared and found to deliver similar results for regions with a high initial signal-to-noise ratio (SNR) within the brain. However, complex averaging is strongly recommended for quantitative applications or for studies where regions of low initial SNR are important. To summarize, a method for high-resolution in vivo anatomical imaging at a clinical field strength is demonstrated and is recommended for brain mapping. The method can also be applied at higher fields with a reduced acquisition time.

Keyword(s): Adult (MeSH) ; Algorithms (MeSH) ; Anisotropy (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Image Enhancement: methods (MeSH) ; Image Interpretation, Computer-Assisted: methods (MeSH) ; Imaging, Three-Dimensional: methods (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Male (MeSH) ; Reproducibility of Results (MeSH) ; Sensitivity and Specificity (MeSH) ; J ; High-resolution MRI (auto) ; 1.5 T (auto) ; Coregistration (auto) ; Averaging (auto) ; Complex averaging (auto) ; In vivo anatomical imaging (auto) ; Brain imaging (auto) ; Volume coverage (auto) ; 0.6-mm isotropic resolution (auto)

Note: We are grateful to the volunteers for their collaboration. The MRI facility is supported by the Bundesministerium far Bildung und Forschung (BMBF) through a grant (BMBF 01GO0104) to N.J.S. and K.Z. This Human Brain Project/Neuroinformatics research is funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health. The support of the BMBF (Brain Imaging Centre West BMBF, 01GO0204) is kindly acknowledged.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
3. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89573 - Neuroimaging (POF2-89573) (POF2-89573)

Appears in the scientific report 2010

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