%0 Journal Article
%A Valk, Sofie L.
%A Xu, Ting
%A Paquola, Casey
%A Park, Bo-yong
%A Bethlehem, Richard A. I.
%A Vos de Wael, Reinder
%A Royer, Jessica
%A Masouleh, Shahrzad Kharabian
%A Bayrak, Şeyma
%A Kochunov, Peter
%A Yeo, B. T. Thomas
%A Margulies, Daniel
%A Smallwood, Jonathan
%A Eickhoff, Simon B.
%A Bernhardt, Boris C.
%T Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
%J Nature Communications
%V 13
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M FZJ-2022-02227
%P 2341
%D 2022
%X Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35534454
%U <Go to ISI:>//WOS:000792848500017
%R 10.1038/s41467-022-29886-1
%U https://juser.fz-juelich.de/record/907808