Journal Article

FZJ-2022-02227

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

Valk, S. L. (Corresponding author)FZJ* ; Xu, T. ; Paquola, C.FZJ* ; Park, B.-y. ; Bethlehem, R. A. I. ; Vos de Wael, R. ; Royer, J. ; Masouleh, S. K.FZJ* ; Bayrak, Ş. ; Kochunov, P. ; Yeo, B. T. T. ; Margulies, D. ; Smallwood, J. ; Eickhoff, S. B.FZJ* ; Bernhardt, B. C.

2022
Nature Publishing Group UK [London]

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/31210  doi:10.1038/s41467-022-29886-1  doi:10.34734/FZJ-2022-02227

Abstract: Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.

---

Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)

Appears in the scientific report 2022

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---