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000907808 1001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L.$$b0$$eCorresponding author
000907808 245__ $$aGenetic and phylogenetic uncoupling of structure and function in human transmodal cortex
000907808 260__ $$a[London]$$bNature Publishing Group UK$$c2022
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000907808 520__ $$aBrain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.
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000907808 7001_ $$00000-0002-0065-3832$$aXu, Ting$$b1
000907808 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b2
000907808 7001_ $$00000-0001-7096-337X$$aPark, Bo-yong$$b3
000907808 7001_ $$0P:(DE-HGF)0$$aBethlehem, Richard A. I.$$b4
000907808 7001_ $$0P:(DE-HGF)0$$aVos de Wael, Reinder$$b5
000907808 7001_ $$00000-0002-4448-8998$$aRoyer, Jessica$$b6
000907808 7001_ $$0P:(DE-Juel1)171719$$aMasouleh, Shahrzad Kharabian$$b7
000907808 7001_ $$0P:(DE-HGF)0$$aBayrak, Şeyma$$b8
000907808 7001_ $$0P:(DE-HGF)0$$aKochunov, Peter$$b9
000907808 7001_ $$0P:(DE-HGF)0$$aYeo, B. T. Thomas$$b10
000907808 7001_ $$00000-0002-8880-9204$$aMargulies, Daniel$$b11
000907808 7001_ $$0P:(DE-HGF)0$$aSmallwood, Jonathan$$b12
000907808 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b13$$ufzj
000907808 7001_ $$00000-0001-9256-6041$$aBernhardt, Boris C.$$b14
000907808 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-022-29886-1$$gVol. 13, no. 1, p. 2341$$n1$$p2341$$tNature Communications$$v13$$x2041-1723$$y2022
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