TY  - JOUR
AU  - Valk, Sofie L.
AU  - Xu, Ting
AU  - Paquola, Casey
AU  - Park, Bo-yong
AU  - Bethlehem, Richard A. I.
AU  - Vos de Wael, Reinder
AU  - Royer, Jessica
AU  - Masouleh, Shahrzad Kharabian
AU  - Bayrak, Şeyma
AU  - Kochunov, Peter
AU  - Yeo, B. T. Thomas
AU  - Margulies, Daniel
AU  - Smallwood, Jonathan
AU  - Eickhoff, Simon B.
AU  - Bernhardt, Boris C.
TI  - Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
JO  - Nature Communications
VL  - 13
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - FZJ-2022-02227
SP  - 2341
PY  - 2022
AB  - Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.
LB  - PUB:(DE-HGF)16
C6  - pmid:35534454
UR  - <Go to ISI:>//WOS:000792848500017
DO  - DOI:10.1038/s41467-022-29886-1
UR  - https://juser.fz-juelich.de/record/907808
ER  -